Week 2 · Wednesday, September 16, 2026
Lions visit Bills on Thursday night to open Week 2
The File desk · Sep 16, 2026, 2:16 PM UTC
Status
Confirmed from NFL.com’s Thursday Night Football and Monday Night Football 2026 prime-time pages, checked Sept. 16, 2026.
Week 2 of the National Football League season starts Thursday night. NFL.com’s 2026 Thursday Night Football page lists Detroit Lions at Buffalo Bills on Thursday, Sept. 17, at 8:15 p.m. Eastern on Prime Video. Monday Night Football in Week 2 is New York Giants at Los Angeles Rams on Sept. 21 at 8:15 p.m. Eastern on ESPN, per the league’s Monday Night Football page. Week 1 is complete, including Kansas City’s 31–10 win over Denver on Monday night. No odds. No picks.
Week 2 of the National Football League season starts Thursday night.
NFL.com’s 2026 Thursday Night Football page lists Detroit Lions at Buffalo Bills on Thursday, Sept. 17, at 8:15 p.m. Eastern on Prime Video.
Monday Night Football in Week 2 is New York Giants at Los Angeles Rams on Sept. 21 at 8:15 p.m. Eastern on ESPN, per the league’s Monday Night Football page.
Week 1 is complete, including Kansas City’s 31–10 win over Denver on Monday night.
No odds. No picks.
What is still unknown or disputed
- Week 2 Sunday afternoon slate not re-listed here beyond the national windows confirmed above.
Primary sources
Every claim in this story is drawn from the documents below. If a fetch failed, that is recorded on the card.
Source 1
NFL 2026 Prime Time Thursday Night Football Schedule
NFL.com · checked 2026-09-16
Lions at Bills, Thursday, September 17th, 8:15 PM, PRIME.
https://www.nfl.com/schedules/2026/prime-time/thursday-night-football
Source 2
NFL 2026 Prime Time Monday Night Football Schedule
NFL.com · checked 2026-09-16
Giants at Rams, Monday, September 21st, 8:15 PM, ESPN.
https://www.nfl.com/schedules/2026/prime-time/monday-night-football
Source 3
2026 NFL Schedule Announced
NFL Media · 2026-05-14 (checked 2026-09-16)
Thursday Night Football Week 2 Bills host Lions 8:15 p.m. ET Prime Video.
https://media.nfl.com/football-information/2026/news/2026-nfl-schedule-announced